"More than 100 pharmacies greatly increased the total amount they billed for compounded topical drugs from 2015 to 2016 There were 110 pharmacies that greatly increased their billing for compounded topicals over the course of just 1 year. Each of these pharmacies increased their billing for these drugs by more than 483 percent from 2015 to 2016. Of note, 20 of these pharmacies increased their billing by more than 10,000 percent. An extreme increase in a pharmacy’s billing may indicate fraud and abuse, especially when the spike is related to a particular type of drug. This may indicate that the pharmacy is billing for drugs that are not medically necessary or never dispensed. "

quoted from report found here